#1 is a surface, #2 is an optional hydrophillic polymer, #3 are clevable linkages, #4 is an anchor provided by reactive polymer chains in the complex, #5 is an embedded and exposed bioactive material.

• Therapeutic agents are released locally from devices to provide maximum benefit where the treatment is most needed.

• Release rate and time period are customized to optimize the clinical benefit.

• Optimized, site-specific dosages are administered without adverse effects common to systemic treatments.

#1 is a surface, #2 is a layer of a reactive anchor containing linker moiety or a linker moiety alone over reactive surface, #3 is a cleavable linkage and #4 is a bioactive material.